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Related Experiment Videos

A chemically intelligent antimicrobial coating for urologic devices.

S Subramanyam1, A Yurkovetsiky, D Hale

  • 1Intelligent Biocides, LLC, Tewksbury, Massachusetts 01876, USA. sundar@ibhome.com

Journal of Endourology
|March 29, 2000
PubMed
Summary

Surfacine, a novel silver-based antimicrobial coating, offers surface-bound infection resistance for medical devices. This contact biocide technology prevents microbial growth without leaching, ensuring safety and efficacy.

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Area of Science:

  • Biomaterials Science
  • Infectious Disease Control
  • Nanotechnology

Background:

  • Contact biocides represent an emerging class of infection-resistant materials.
  • Alloplastic materials are widely used in medical device fabrication.
  • Developing effective surface-based antimicrobial strategies is crucial for preventing device-associated infections.

Purpose of the Study:

  • To evaluate Surfacine, a silver-based antimicrobial coating, for its efficacy and safety.
  • To assess the surface-bound antimicrobial activity of Surfacine on alloplastic materials.
  • To determine if Surfacine induces antimicrobial activity in contacting fluids.

Main Methods:

  • Immobilization of a silver-based antimicrobial coating (Surfacine) onto various alloplastic materials.

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  • Testing for broad-spectrum antimicrobial activity exclusively at the material surface.
  • Assessing the elution properties of the coating into contacting fluids (e.g., urine).
  • Evaluating the biocompatibility of the immobilized coating, including potential toxicity, immunogenicity, teratogenicity, and carcinogenicity.

    • Main Results:

    • Surfacine demonstrated broad-spectrum antimicrobial activity localized to the material surface.
    • The coating did not exhibit elution into contacting fluids, irrespective of fluid volume.
    • Antimicrobial activity was exclusively surface-dependent, with no effect on surrounding fluids.
    • Permanently immobilized Surfacine showed no signs of cell toxicity and is not anticipated to be immunogenic, teratogenic, or carcinogenic.

    Conclusions:

    • Surfacine is an effective silver-based antimicrobial coating for infection resistance on medical devices.
    • Its surface-bound, non-eluting nature ensures localized antimicrobial action and enhances safety.
    • The coating's biocompatibility profile suggests a low risk of adverse biological reactions.