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Related Experiment Videos

Tissue engineering of artificial organs.

A Atala1

  • 1Department of Urology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Atala@a1.tch.harvard.edu

Journal of Endourology
|March 29, 2000
PubMed
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Tissue engineering is advancing genitourinary treatments, with initial human applications for vesicoureteral reflux and urinary incontinence. Future clinical uses for engineered urologic tissues show promise.

Area of Science:

  • Regenerative Medicine
  • Urology
  • Biomaterials

Background:

  • Significant advancements in tissue engineering for genitourinary tissues have emerged in the past decade.
  • Successful tissue engineering requires expertise in growth factor biology, specialized cell culture, and scaffold manufacturing.

Purpose of the Study:

  • To review the current state and future potential of tissue engineering in urology.
  • To highlight the initial human applications and ongoing trials of engineered urologic tissues.

Main Methods:

  • Review of current tissue engineering techniques and their application in urologic research.
  • Description of the first human application of cell-based tissue engineering for vesicoureteral reflux.
  • Overview of ongoing trials for urethral and bladder tissue replacement.

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Main Results:

  • The first human application involved autologous cell injection for pediatric vesicoureteral reflux correction.
  • The technology has been extended to treat adult urinary incontinence.
  • Clinical trials for urethral and bladder tissue replacement are underway.

Conclusions:

  • Engineered urologic tissues have demonstrated initial clinical success in pediatric and adult patients.
  • Ongoing trials suggest a strong potential for future clinical applicability of tissue-engineered urologic organs.
  • Further research is necessary to fully realize the potential of these advanced regenerative medicine techniques.