Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biologically variable pulsation improves jugular venous oxygen saturation during rewarming.

W A Mutch1, R K Warrian, G M Eschun

  • 1Department of Anesthesia, University of Manitoba, Winnipeg, Canada. amutch@ms.umanitoba.ca

The Annals of Thoracic Surgery
|March 29, 2000
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fractal or biologically variable delivery of cardioplegic solution prevents diastolic dysfunction after cardiopulmonary bypass.

The Journal of thoracic and cardiovascular surgery·2002
Same author

Income-based drug benefit policy: impact on receipt of inhaled corticosteroid prescriptions by Manitoba children with asthma.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2001
Same author

Biologic variability in mechanical ventilation in a canine oleic acid lung injury model.

American journal of respiratory and critical care medicine·2001
Same author

Biologically variable ventilation increases arterial oxygenation over that seen with positive end-expiratory pressure alone in a porcine model of acute respiratory distress syndrome.

Critical care medicine·2000
Same author

Biologically variable or naturally noisy mechanical ventilation recruits atelectatic lung.

American journal of respiratory and critical care medicine·2000
Same author

How Baby-Friendly are Manitoba hospitals? The Provincial Infant Feeding Study. Breastfeeding Promotion Steering Committee of Manitoba.

Canadian journal of public health = Revue canadienne de sante publique·2000

Biologically variable pulsatile (BVP) bypass better preserves jugular venous oxygen saturation (SjvO2) during rewarming from cardiopulmonary bypass (CPB). This computer-controlled method significantly reduces instances of low SjvO2, indicating improved cerebral oxygenation.

Area of Science:

  • Cardiovascular Physiology
  • Bypass Technology
  • Cerebral Oxygenation

Background:

  • Conventional pulsatile (CP) cardiopulmonary bypass (CPB) lacks biological variability.
  • Low jugular venous oxygen saturation (SjvO2) during rewarming from CPB is linked to cognitive dysfunction.
  • Computer-controlled biologically variable pulsatile (BVP) bypass aims to restore physiological flow patterns.

Purpose of the Study:

  • To compare the efficacy of CPB versus BVP in maintaining SjvO2 during rewarming.
  • To assess the impact of BVP on cerebral oxygenation compared to CPB.

Main Methods:

  • Pigs underwent 3-hour CPB with alpha-stat management and arterial filtration.
  • Animals were randomized to either CP or computer-controlled BVP during cooling to 28°C.

Related Experiment Videos

  • SjvO2 was measured at 5-minute intervals during rewarming, with analysis of mean and cumulative areas below 50%.

    • Main Results:

    • No significant differences in temperature, mean arterial pressure, or blood gas levels between groups.
    • BVP demonstrated a wider systolic pressure range (41 ± 18 mm Hg) compared to CP (12 ± 4 mm Hg).
    • CPB showed significantly higher mean and cumulative areas for SjvO2 < 50% (p=0.004) compared to BVP.

    Conclusions:

    • Computer-controlled BVP significantly enhances SjvO2 during rewarming from hypothermic CPB.
    • The ratio of low SjvO2 events (area under the curve) was over 20:1 in favor of BVP.
    • BVP improves cerebral oxygenation during rewarming from moderate hypothermia by restoring biological flow variability.