Related Experiment Video
Updated: Jan 4, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Injection of vasodilators into arterial grafts through cardiac catheter to relieve spasm
1Department of Surgery, University of Hong Kong, Grantham Hospital, China. gwhe@hkucc.hku.hk
Insights
Coronary artery bypass grafting can lead to vasospasm in grafts and native arteries. Prompt arteriogram with intraluminal vasodilators like calcium antagonists and nitroglycerin can effectively treat this potentially life-saving condition.
Area of Science:
- Cardiology
- Vascular Surgery
Background:
- Coronary artery bypass grafting (CABG) is a common procedure for coronary artery disease.
- Both native coronary arteries and bypass grafts are susceptible to vasospasm post-CABG.
Observation:
- Vasospasm can occur in arterial grafts and native coronary arteries after bypass surgery.
- Standard vasodilator therapies may be ineffective for certain vasospasm cases.
Findings:
- A high suspicion of vasospasm warrants a prompt selective graft arteriogram.
- Intraluminal administration of vasodilators, including calcium antagonists and nitroglycerin, can effectively manage arterial vasospasm.
- This therapeutic approach can be life-saving.
Implications:
- Selective graft arteriography is a valuable diagnostic tool for post-CABG vasospasm.
- Intraluminal vasodilator therapy offers a targeted and effective treatment for refractory vasospasm.
- This intervention can improve outcomes and potentially save lives in patients experiencing graft dysfunction due to vasospasm.
Abstract:
Both native coronary artery and coronary bypass grafts may develop vasospasm after coronary artery bypass grafting. We recommend that whenever there is a high suspicion of vasospasm in arterial grafts and the native coronary artery unresponsive to or not suitable for usual vasodilator therapy, prompt selective graft arteriogram should be performed. Intraluminal injection of vasodilators such as calcium antagonists in combination with nitroglycerin may provide an effective antispastic therapy and this procedure could be lifesaving as demonstrated in the present report.
Related Concept Videos
Peripheral Artery Disease III: Interprofessional Care
Coronary Artery Disease V: Interprofessional Care
Antihypertensive Drugs: Vasodilators
Vascular Spasm

