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Electrophysiological end point for catheter ablation of atrial fibrillation initiated from multiple pulmonary venous foci.

M Haïssaguerre1, P Jaïs, D C Shah

  • 1Hôpital Cardiologique du Haut-Lévêque, Bordeaux-Pessac, France.

Circulation
|March 29, 2000

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View abstract on PubMed

Summary

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  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Electrophysiological End Point For Catheter Ablation Of Atrial Fibrillation Initiated From Multiple Pulmonary Venous Foci.
    • This summary is machine-generated.

    Catheter ablation for atrial fibrillation (AF) is more successful when distal pulmonary vein (PV) potentials are eliminated. Multiple PV foci often initiate AF, and their abolition correlates with improved clinical outcomes.

    Area of Science:

    • Cardiology
    • Electrophysiology
    • Medical Devices

    Background:

    • The definitive endpoint for catheter ablation of pulmonary vein (PV) foci initiating atrial fibrillation (AF) remains undetermined.
    • Identifying the precise ablation target is crucial for successful AF treatment.

    Purpose of the Study:

    • To determine the procedural endpoint for catheter ablation of PV foci triggering AF.
    • To correlate procedural success with the abolition of distal PV potentials.

    Main Methods:

    • Ninety patients underwent electrophysiological mapping during AF or ectopy.
    • Ostial PV ablation guided by angiograms targeted arrhythmogenic foci.
    • Success was defined as AF elimination without antiarrhythmic drugs.

    Main Results:

    • 197 arrhythmogenic PV foci and 6 atrial foci were identified.
    • Elimination of distal PV potentials was associated with higher clinical success rates (90% vs. 55%).
    • Clinical success rates decreased with an increasing number of arrhythmogenic PV foci (93% for 1, 73% for 2, 55% for >2).

    Conclusions:

    • Multiple PV foci frequently initiate AF.
    • Abolition of PV muscle conduction, indicated by the disappearance of distal PV potentials, is linked to successful AF ablation.

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