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Ion-Ion interactions at the selectivity filter. Evidence from K(+)-dependent modulation of tetraethylammonium
1Department of Physiology, University of Connecticut, Storrs, Connecticut 06269, USA.
The Journal of General Physiology
|March 29, 2000
Abstract:
In the Kv2.1 potassium channel, binding of K(+) to a high-affinity site associated with the selectivity filter modulates channel sensitivity to external TEA. In channels carrying Na(+) current, K(+) interacts with the TEA modulation site at concentrations