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Agents for treatment of invasive fungal infections
B Luna1, R H Drew, J R Perfect
1Campbell University School of Pharmacy, Buies Creek, North Carolina, USA.
Abstract:
The incidence of fungal infections continues to rise as the population of immunocompromised individuals increases. Despite the enlarging numbers of infections, there are only a few antifungal agents for treatment of deep-seated, invasive infections. These agents include amphotericin B, flucytosine, terbinafine, and several azoles. Progress has been made in understanding the role of these agents in a variety of infections and this article examines in detail these agents and their prophylactic, empiric, and therapeutic uses in invasive mycoses. This article focuses on general concepts of antifungal therapies and provides a detailed review of each antifungal agent available for treatment of deep-seated mycoses.
Insights
Fungal infections are increasing, but treatment options for deep-seated infections remain limited. This review details available antifungal agents and their uses in invasive mycoses.
Area of Science:
- Mycology
- Infectious Diseases
- Pharmacology
Background:
- Rising incidence of invasive fungal infections.
- Growing population of immunocompromised patients.
- Limited therapeutic options for deep-seated mycoses.
Purpose of the Study:
- To review current antifungal agents for invasive mycoses.
- To detail the prophylactic, empiric, and therapeutic applications of antifungals.
- To provide a comprehensive overview of antifungal therapies.
Main Methods:
- Literature review of antifungal agents.
- Analysis of clinical applications in invasive mycoses.
- Examination of prophylactic, empiric, and therapeutic uses.
Main Results:
- Identified key antifungal agents: amphotericin B, flucytosine, terbinafine, and azoles.
- Detailed the roles of these agents in various fungal infections.
- Summarized general concepts and specific uses of antifungals.
Conclusions:
- Amphotericin B, flucytosine, terbinafine, and azoles are crucial for treating invasive mycoses.
- Understanding the application of these agents is vital for patient management.
- Continued research is needed to expand antifungal treatment options.