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Published on: March 9, 2018
Invasive fungal sinusitis in the acquired immunodeficiency syndrome
S M Hunt1, R C Miyamoto, R S Cornelius
1Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
Otolaryngologic Clinics of North America
|March 29, 2000
Summary
Invasive fungal sinusitis in patients with Acquired Immunodeficiency Syndrome (AIDS) often presents subtly. Early diagnosis of this opportunistic infection, particularly Aspergillus fumigatus, is crucial for prompt intervention.
Area of Science:
- Mycology
- Infectious Diseases
- Immunocompromised Hosts
Background:
- Invasive fungal sinusitis (IFS) is a severe opportunistic infection affecting immunocompromised individuals.
- Patients with Acquired Immunodeficiency Syndrome (AIDS) are particularly susceptible to IFS.
- This review analyzes clinical characteristics of IFS in AIDS patients.
Observation:
- Four new cases of IFS in patients with AIDS were analyzed.
- Twenty-two previously reported cases of IFS in AIDS patients were reviewed.
- Common findings include facial pain disproportionate to imaging, low CD4 counts (<50 cells/mm³), low absolute neutrophil counts (<1,000 cells/mm³), subtle radiographic signs, and an indolent course.
Findings:
- Aspergillus fumigatus was the most frequently identified pathogen.
- Subtle clinical and radiographic findings can indicate invasive fungal sinusitis.
- An indolent clinical course is characteristic of IFS in this population.
Implications:
- A high index of suspicion is necessary for early diagnosis of IFS in AIDS patients.
- Critical assessment of clinical symptoms and CT scans aids in timely diagnosis.
- Prompt intervention is essential for managing invasive fungal sinusitis in immunocompromised patients.
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