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Updated: Jul 24, 2026

Live Imaging of Glial Cell Migration in the Drosophila Eye Imaginal Disc
Published on: July 9, 2009
Developmental regulation of cell migration. Insight from a genetic approach in Drosophila
1Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205-2185, USA. denise.montell@qmail.bs.jhu.edu
Abstract:
Cell movements are fascinating and dramatic features of normal animal development. Moreover, failures in cell migration can lead to birth defects, and inappropriate cell migration can lead to cancer metastasis. Genetic approaches are beginning to provide some insights into the molecular basis for the developmental regulation of cell migration. This review discusses the progress that has been made in understanding the regulation of cell migration during Drosophila development, using a molecular genetic approach. In particular, these studies have implicated signaling through a receptor tyrosine kinase in the spatial control of migration. Reorganization of the cytoskeleton, under the control of the guanosine triphosphatase, Rac, is also critical for cell migration. Finally, genetic studies have demonstrated that the timing of cell migration is under transcriptional control.
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