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Related Experiment Videos

[Coping with stress in the elderly].

O Nishikaze1, E Furuya

  • 1Hokkaido University.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|March 29, 2000
PubMed
Summary
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Living organisms balance "wear and tear" with "repair and recovery." Researchers identified 17-ketosteroid sulfates (17-KS-S) as key to repair, noting lower levels in elderly individuals and a link to lifestyle improvements.

Area of Science:

  • Gerontology
  • Biochemistry
  • Stress Physiology

Context:

  • Organisms maintain a dynamic equilibrium between physiological damage ('wear and tear') and restorative processes ('repair and recovery').
  • 17-hydroxycorticosteroids (17-OHCS) are associated with 'wear and tear', prompting a search for markers of 'repair and recovery'.

Purpose:

  • To identify a biochemical marker associated with tissue repair and recovery.
  • To investigate the role of 17-ketosteroid sulfates (17-KS-S) in physiological adaptability, particularly in elderly individuals.

Summary:

  • 17-ketosteroid sulfates (17-KS-S) were identified in urine as compounds related to tissue repair and recovery.
  • Elderly individuals exhibit lower urinary 17-KS-S levels and diminished diurnal variations compared to younger adults.

Related Experiment Videos

  • Significant life events can decrease 17-KS-S levels in the elderly, which may remain low long-term.
  • Improved lifestyle factors (diet, exercise, rest) in frail elderly individuals correlate with increased 17-KS-S levels, suggesting enhanced adaptive capacity.

    • Impact:

    • Highlights 17-KS-S as a potential biomarker for assessing the body's repair and recovery status.
    • Suggests that lifestyle interventions can positively influence physiological adaptability and stress response in the elderly.
    • Provides insights into the biochemical differences in stress adaptation between young and elderly populations.