Related Experiment Videos
Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
J H de Wilt1, T L ten Hagen, G de Boeck
1Department of Surgical Oncology, University Hospital Rotterdam Dijkzigt/Daniel den Hoed Cancer Centre, The Netherlands.
British Journal of Cancer
|March 29, 2000
Abstract:
Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-alpha) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-alpha was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-alpha in ILP.