Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developmental patterning of the myocardium.

D Sedmera1, T Pexieder, M Vuillemin

  • 1Institute of Physiology, University of Lausanne, Lausanne, Switzerland. sedmerad@musc.edu

The Anatomical Record
|March 29, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Form follows function": the developmental morphology of the cardiac atria.

Physiological research·2025
Same author

An engineered enzyme embedded into PLA to make self-biodegradable plastic.

Nature·2024
Same author

What Is the Optimal Light Source for Optical Mapping Using Voltage- and Calcium-Sensitive Dyes?

Physiological research·2020
Same author

Cardiac Enlargement in the Chick Embryo Induced by Hypothermic Incubation Is Due to a Combination of Hyperplasia and Hypertrophy of Cardiomyocytes.

Folia biologica·2019
Same author

Acute temperature effects on function of the chick embryonic heart.

Acta physiologica (Oxford, England)·2016
Same author

Physiological role of FGF signaling in growth and remodeling of developing cardiovascular system.

Physiological research·2016

Heart development involves complex myocardial organization, forming chambers and unique trabecular patterns. Understanding these developmental rules is crucial for human heart development research.

Area of Science:

  • Developmental Biology
  • Cardiovascular Science
  • Comparative Anatomy

Background:

  • The vertebrate heart develops from a simple tube into a four-chambered organ.
  • Myocardial organization changes significantly during cardiac development, including trabeculation and compaction.
  • Trabeculations increase myocardial mass without coronary circulation and form species-specific patterns.

Purpose of the Study:

  • To review variations in heart development processes across species.
  • To compare human heart development with that of laboratory animals (chick, mouse, rat) and lower vertebrates.
  • To highlight the functional importance of myocardial organization and its relevance to human heart development.

Main Methods:

  • Comparative analysis of cardiac development across species.

Related Experiment Videos

  • Review of existing literature on myocardial organization and morphogenesis.
  • Examination of developmental processes in human, chick, mouse, and rat hearts.

    • Main Results:

    • Cardiac development involves the emergence of ventricular trabeculations and the formation of a compact myocardial layer with spiral architecture.
    • Atrial trabeculations form pectinate muscles, aiding in distinguishing right from left atria.
    • Despite variations, hearts share common biomechanical principles, and perturbed myocardial architecture is lethal in mouse mutants.

    Conclusions:

    • Myocardial organization follows conserved biomechanical rules across vertebrates.
    • Experimental studies on myocardial assembly provide insights into human heart development.
    • Understanding developmental variations is key to comprehending cardiac morphogenesis and function.