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Related Experiment Videos

Inhaled mannitol identifies methacholine-responsive children with active asthma.

P Subbarao1, J D Brannan, B Ho

  • 1Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Pediatric Pulmonology
|March 29, 2000
PubMed
Summary

Inhaled mannitol effectively identifies airway hyperresponsiveness in children with asthma, proving faster than methacholine challenge testing. This method offers a quicker diagnosis for pediatric asthma.

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Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Clinical Diagnostics

Background:

  • Bronchial challenge testing is crucial for diagnosing asthma and airway hyperresponsiveness.
  • Methacholine challenge is a standard but time-consuming diagnostic tool.
  • Inhaled mannitol has emerged as a potential alternative for bronchial provocation.

Purpose of the Study:

  • To evaluate inhaled mannitol's efficacy in identifying active asthma in children.
  • To compare the speed of mannitol challenge versus methacholine challenge.
  • To assess mannitol's repeatability and safety in pediatric patients.

Main Methods:

  • A comparative study involving 25 children with asthma and 10 non-asthmatic children.
  • Sequential methacholine (Cockcroft protocol) and mannitol challenges were administered on separate days.

Related Experiment Videos

  • Spirometry (FEV1) was used to measure airway response, with PD15 for mannitol and PC20 for methacholine determined.

    • Main Results:

    • Twenty-one out of 25 asthmatic children tested positive for airway hyperresponsiveness to mannitol.
    • Mannitol challenge was significantly faster (14 min) than methacholine challenge (29 min).
    • Mannitol responses were repeatable, with no significant safety concerns or drops in oxygen saturation.

    Conclusions:

    • Inhaled mannitol is a reliable and faster method for diagnosing airway hyperresponsiveness in children with asthma.
    • Mannitol challenge offers a more efficient alternative to methacholine testing in pediatric populations.
    • This study supports mannitol's utility in clinical settings for pediatric asthma diagnosis.