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Increased expression of sialyl Le(x) antigen in non-polypoid growth type of colorectal carcinoma
T Nakagoe1, K Fukushima, A Nanashima
1First Department of Surgery, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, Japan. nakagoe@net.nagasaki-u.ac.jp
Abstract:
Colorectal carcinoma can be morphologically divided into two different categories, namely polypoid growth (PG-type) and non-polypoid growth (NPG-type). To ascertain whether the expression of sialyl Le(x) antigen correlates with biologically and clinically important differences, an immunohistochemical assay was performed in 30 PG-type and 119 NPG-type cancers. In contrast to PG-type, the characteristics of the NPG-type include (1) an increased expression of sialyl Le(x); (2) a high rate of lymph node metastasis; (3) a high proportion of moderately differentiated adenocarcinoma cells; (4) young age of onset. It is concluded that differences in sialyl Le(x) expression between the PG-type and NPG-type cancers may be at least partly responsible for different tumor progression behavior.
