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[Paraneoplastic neuropathies].

C Mallecourt1, J Y Delattre

  • 1Fédération de Neurologie Mazarin, Hôpital de la Salpêtrière, Paris.

Presse Medicale (Paris, France : 1983)
|March 30, 2000
PubMed
Summary
This summary is machine-generated.

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Paraneoplastic neuropathies (PN) are rare neurological disorders associated with cancer, often preceding diagnosis. Early identification of these diverse conditions is crucial for patient management.

Area of Science:

  • Neurology
  • Oncology

Context:

  • Paraneoplastic neuropathies (PN) affect 4-5% of cancer patients.
  • Diagnosis is challenging due to nonspecific symptoms and neuropathy preceding cancer detection.

Purpose:

  • To review the diverse clinical presentations of paraneoplastic neuropathies.
  • To highlight key associations between specific neuropathies and cancer types.

Summary:

  • Subacute sensory neuropathy (SSN) involves severe dorsal root ganglion inflammation, often linked to small-cell lung cancer (SCLC) and anti-Hu antibodies.
  • Sensorimotor neuropathies are common and heterogeneous, including Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, and microvasculitis.
  • Autonomic neuropathies, often presenting as pseudo-obstruction, occur with SCLC or Hodgkin's disease.

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Impact:

  • Improved understanding of rare neurological complications of cancer.
  • Enhanced diagnostic strategies for paraneoplastic syndromes.
  • Facilitates earlier cancer detection and targeted treatment.