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[Diesel particles and allergy: cellular mechanisms]
A Chambellan1, B Crestani, P Soler
1Unité INSERM 408-CHU Bichat, Paris.
Allergie Et Immunologie
|March 30, 2000
Summary
Diesel exhaust particles worsen asthma and allergic rhinitis by acting as immune adjuvants. These pollutants enhance allergic inflammation through complex interactions with immune cells and pathways.
Area of Science:
- Environmental Health
- Immunology
- Toxicology
Context:
- Urban air pollution, especially diesel exhaust particles (DEP), is linked to rising rates of asthma and allergic rhinitis.
- Epidemiological and experimental studies confirm DEP's role in exacerbating allergic diseases.
Purpose:
- To review the mechanisms by which diesel exhaust particles contribute to allergic inflammation.
- To discuss the synergistic interactions between DEP components, allergens, and immune pathways.
Summary:
- DEP function as immune adjuvants, enhancing allergic responses.
- Mechanisms involve altered cytokine/chemokine production and immune cell activation.
- Polycyclic aromatic hydrocarbons and allergens interact with DEP, promoting IgE production and allergic inflammation.
Impact:
- Provides a comprehensive overview of DEP's impact on allergic diseases.
- Highlights key molecular and cellular pathways involved in DEP-induced inflammation.
- Informs strategies for mitigating the health effects of air pollution on allergic conditions.