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Lubricant susceptibility of Cellactose and Avicel PH-200: a quantitative relationship
L Estrada Flores1, R López Arellano, J J Díaz Esquivel
1Section of Pharmaceutical Technology, Facultad de Estudios Superiores Cuautitlan UNAM, México.
Drug Development and Industrial Pharmacy
|March 30, 2000
Abstract:
The lubricant susceptibility of two direct compression excipients, Avicel PH-200 and Cellactose, was determined using a model mix with metamizol sodium (dipyrone) and designed experiments to obtain a quantitative relationship by multiple regression. As a result, a new constant called specific lubricant sensibility Ls is proposed for the comparison of lubricant susceptibility in other drug-excipient systems.