Poly epsilon-caprolactone nanoparticles containing a poorly soluble pesticide: formulation and stability study

In 1997, a research program was initiated in the laboratories to assess the ability of nanosperes (NS) to improve the biodelivery of new active ingredients (AI) to plants. The goal was to obtain stable poly (epsilon-caprolactone) NS (PeC-NS) with the smallest size and the largest amount of encapsulated AI, using a nanoprecipitation method. The smallest particles obtained were in the range of 200-250 nm. The highest encapsulation is obtained with Montanox 80 as surfactant and is between 5-10% (expressed in per cent weight relative to the total weight of polymer), which corresponds to an encapsulation yield of 95%. There is no desorption of the AI with time. In contrast, the dilution of the NS suspension in water is followed by a large removal of the AI in the aqueous phase. This suggests that NS are complex dynamic systems in equilibrium with the external medium and disturbances of this system lead to a loss of AI.