Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of PCDD/F levels in human blood from Germany over the past ten years (1989-1998).

J Wittsiepe1, P Schrey, U Ewers

  • 1Ruhr-Universität Bochum, Abteilung für Hygiene, Sozial- und Umweltmedizin, Germany. wittsiepe@hygiene.ruhr-uni-bochum.de

Chemosphere
|March 30, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alleviating the burden of depression: a simulation study on the impact of mental health services.

Epidemiology and psychiatric sciences·2024
Same author

Really just a little prick? A meta-analysis on adverse events in placebo control groups of seasonal influenza vaccination RCTs.

Vaccine·2022
Same author

Diagnostic yield and cost analysis of electrocardiographic screening in Swiss paediatric athletes.

Journal of science and medicine in sport·2021
Same author

EU-CaRE study: Could exercise-based cardiac telerehabilitation also be cost-effective in elderly?

International journal of cardiology·2021
Same author

Acute and chronic effects of high-intensity interval and moderate-intensity continuous exercise on heart rate and its variability after recent myocardial infarction: A randomized controlled trial.

Annals of physical and rehabilitation medicine·2020
Same author

Transfer mechanisms in semiconductor hybrids with colloidal core/shell quantum dots on ZnSe substrates.

Nanotechnology·2020

Human blood levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) significantly decreased from 1989 to 1998. Blood PCDD/F concentrations showed a positive correlation with age in German adults during this period.

Area of Science:

  • Environmental Chemistry
  • Toxicology
  • Human Health Risk Assessment

Background:

  • Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) are persistent organic pollutants with known toxic effects.
  • Monitoring human exposure levels is crucial for assessing environmental health risks.

Purpose of the Study:

  • To analyze temporal trends and age-related correlations of PCDD/F concentrations in human blood.
  • To quantify changes in PCDD/F exposure in the German population over a decade.

Main Methods:

  • Analysis of 744 whole blood samples from German subjects collected between 1989 and 1998.
  • Capillary gas chromatography/high resolution mass spectrometry (GC/HRMS) for PCDD/F quantification.
  • Statistical modeling (multiplicative and linear) to assess age and time correlations.

Related Experiment Videos

Main Results:

  • A continuous decrease in mean PCDD/F concentrations was observed, from 43.7 pg I-TEq/g in 1989 to 20.7 pg I-TEq/g in 1996/98.
  • Most PCDD/F congeners showed a reduction of approximately 50% over the study period.
  • A positive correlation between PCDD/F blood levels and age was found for most congeners and toxicity equivalents.

Conclusions:

  • Human blood PCDD/F levels in Germany declined significantly between 1989 and 1998.
  • Age is a significant factor influencing PCDD/F accumulation in human blood.
  • The findings provide valuable data for understanding long-term exposure trends and risk factors.