An unusual death by propranolol ingestion

Area of Science:

• Toxicology
• Pharmacology
• Forensic Science

Background:

• Propranolol, a beta-blocker, is commonly prescribed for cardiovascular conditions.
• Acute intoxication can lead to severe adverse effects, including cardiovascular collapse.
• Accurate detection and quantification are crucial in forensic toxicology cases.

Observation:

• A deceased 60-year-old male was discovered in his vehicle.
• No signs of trauma or asphyxia were present.
• A propranolol (Inderal) packaging was found near the body, suggesting potential drug ingestion.

Findings:

• High blood propranolol levels confirmed acute intoxication.
• Gas chromatography/mass spectrometry identified and quantified propranolol.
• The case suggests propranolol overdose as the cause of death.

Implications:

• This case underscores the potential lethality of acute propranolol overdose.
• Highlights the importance of forensic analysis in determining cause of death.
• Emphasizes the need for careful medication management and awareness of overdose risks.