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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
Published on: December 27, 2016
Serine/threonine protein kinases and apoptosis
T G Cross1, D Scheel-Toellner, N V Henriquez
1MRC Centre for Immune Regulation, The Medical School, Birmingham, B15 2TT, United Kingdom.
Experimental Cell Research
|March 31, 2000
Summary
Protein kinases regulate programmed cell death (apoptosis). This review highlights serine/threonine kinases like MAPK, PKA, PKB/Akt, and PKC in apoptosis induction and execution.
Area of Science:
- Molecular Biology
- Cell Biology
Background:
- Apoptosis, or programmed cell death, is a fundamental cellular process.
- Understanding apoptosis has advanced significantly, identifying key components and regulatory mechanisms.
- Extrinsic factors like hormones, growth factors, and cellular stress modulate apoptosis.
Purpose of the Study:
- To review the critical role of protein kinases in apoptosis.
- To focus on serine/threonine protein kinases involved in apoptosis.
- To discuss the involvement of specific kinases in apoptosis regulation.
Main Methods:
- Literature review focusing on protein kinases and apoptosis.
- Analysis of the role of serine/threonine protein kinases in apoptosis.
- Brief consideration of tyrosine kinase regulation of these pathways.
Main Results:
- Protein kinases are implicated in both the induction and execution phases of apoptosis.
- Specific serine/threonine kinases, including MAPK family members (p42/44 ERK, p38 MAPK, JNK), PKA, PKB/Akt, and PKC, play roles in apoptosis.
- Tyrosine kinases, such as c-abl, may also regulate these apoptotic kinases.
Conclusions:
- Protein kinases are central regulators of apoptosis.
- Serine/threonine kinases are key players in the complex apoptotic pathway.
- Further research into kinase regulation offers insights into controlling programmed cell death.
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