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Updated: Oct 16, 2026
Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
Published on: July 18, 2016
Alpha-fetoprotein production by a malignant mixed Müllerian tumor of the ovary
C Rebischung1, P Pautier, P Morice
1Department of Medicine, Department of Surgery, Department of Pathology, Institut Gustave Roussy, 39 rue Camille-Desmoulin, Villejuif, 94805, France.
Abstract:
Elevated levels of alpha-fetoprotein (AFP), a fetal serum protein, usually signal the development of hepatoma or germ cell tumors, including endodermal sinus tumors. We report the case of a 52-year-old woman with an alpha-fetoprotein-producing malignant mixed Müllerian tumor (MMMT) of the ovary. Serum AFP was 5348 ng/ml at diagnosis. Immunohistochemistry confirmed that the carcinomatous component of this biphasic tumor was the seat of AFP production. After three cycles of combination chemotherapy, the patient achieved a complete remission. Serum AFP was strongly correlated with response to treatment. This is the first report of AFP production by a MMMT of the ovary without a yolk sac component.
