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Rapid Generation of Amyloid from Native Proteins In vitro
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alpha-L-iduronidase forms semi-crystalline spherulites with amyloid-like properties

L Ruth1, D Eisenberg, E F Neufeld

  • 1Department of Biological Chemistry and Molecular Biology Institute, University California Los Angeles, Los Angeles, CA 90095, USA.

Acta Crystallographica. Section D, Biological Crystallography
|March 31, 2000
PubMed
Summary

Researchers found that soluble human alpha-L-iduronidase can form solid, amyloid-like spherulites under specific conditions. These protein aggregates share characteristics with amyloidogenic proteins and interact with heparin.

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