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[Familial amyloid polyneuropathy type I complicated by chronic glaucoma: 3 cases]
E Frau1, M Lautier-Frau, F Saindelle-Ribeaudeau
1Service d'Ophtalmologie, CHU de Bicêtre, 78, avenue du Général Leclerc, 94270 Le Kremlin Bicêtre, France.
Purpose:
We report 3 cases of familial amyloid polyneuropathy type I (FAP) with amyloid infiltration of the vitreum and glaucoma.
Patients And Methods:
We reviewed the records of three patients, 2 females and one male, aged 41, 47 and 83 years respectively. The 3 patients had familial amyloid polyneuropathy type I with vitreous infiltration and open angle glaucoma. The two women underwent a liver graft four years earlier. Vitrectomy allowed confirmation of the diagnosis in the 83-year-old patient. Two patients underwent trabeculectomy, histological analysis of the iris and the trabeculum was obtained for one patient.
Results:
The tree patients presented a polyneuropathy, vitreous infiltration and open angle glaucoma. Results of light microscopy of the iris and the trabeculum showed amyloid deposits in the iris and the trabecular meshworks.
Conclusion:
Familial amyloid polyneuropathy is a hereditary disease which may have a wide range of ocular manifestations. Glaucoma is among the most serious complications of familial amyloid polyneuropathy.