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Does ceramide play a role in neural cell apoptosis?
Journal of Neuroscience Research
|March 31, 2000
Summary
Ceramide, a lipid messenger, triggers cell death pathways and diverse responses like apoptosis. This review examines ceramide
Area of Science:
- Biochemistry
- Cell Biology
- Neuroscience
Background:
- Ceramide is a lipid second messenger.
- It is generated by various stimuli including receptor activation, growth factor withdrawal, chemotherapy, radiation, and oxidative stress.
- Ceramide elicits diverse cellular responses such as apoptosis, cell-cycle arrest, differentiation, and proliferation.
Purpose of the Study:
- To review the evidence for ceramide's role in apoptosis within nervous system cells.
Main Methods:
- Literature review of studies investigating ceramide and apoptosis in neural cells.
Main Results:
- Ceramide is implicated in apoptosis in various cell types.
- Specific evidence regarding its role in nervous system cells is examined.
Conclusions:
- Ceramide plays a significant role in the induction of apoptosis in cells of the nervous system.