Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Phenotypic classification of malignant lymphoma].

Y Kaneita1, K Yasukawa, Y Kura

  • 1First Department of Internal Medicine, Nihon University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 31, 2000
PubMed
Summary

Flow cytometry aids lymphoma diagnosis by analyzing cell markers. Specific changes in surface immunoglobulin, CD5/CD23, CD2, and CD19 levels help identify B-cell lymphomas and related conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emergency care accessibility for undocumented migrants in Japan: why are they not covered?

QJM : monthly journal of the Association of Physicians·2023
Same author

Hepatocellular uptake index obtained with gadoxetate disodium-enhanced magnetic resonance imaging in the assessment future liver remnant function after major hepatectomy for biliary malignancy.

BJS open·2021
Same author

Effects of prolonged exposure to CO<sub>2</sub> on behaviour, hormone secretion and respiratory muscles in young female rats.

Physiology & behavior·2017
Same author

Separation of Neutral Glycoasparagines According to Their Content of cis Diol Groups.

Bioscience, biotechnology, and biochemistry·2016
Same author

Diagnostics: Cluster headache and misuse of paracetamol.

British dental journal·2016
Same author

Genetic diversity does not explain variation in extra-pair paternity in multiple populations of a songbird.

Journal of evolutionary biology·2015

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Context:

  • Accurate diagnosis of lymphoma is crucial for effective treatment.
  • Traditional diagnostic methods can be time-consuming and require specialized expertise.
  • Flow cytometry offers a rapid and sensitive approach for analyzing cell surface markers.

Purpose:

  • To evaluate the utility of flow cytometry in diagnosing lymphoma using fresh biopsy samples.
  • To identify specific flow cytometry patterns indicative of different types of B-cell lymphomas.

Summary:

  • Analysis of surface immunoglobulin kappa/lambda ratio can detect monoclonal B-cell proliferation.
  • Increased CD5/CD23 double-positive cells suggest B-cell chronic lymphocytic leukemia or small lymphocytic lymphoma.
  • Decreased CD2 and increased CD19 expression indicate B-cell lymphoma.

Related Experiment Videos

Impact:

  • Flow cytometry provides valuable adjunctive information for lymphoma diagnosis.
  • This technique can improve diagnostic accuracy and potentially expedite treatment decisions.
  • The findings support the integration of flow cytometry into routine lymphoma diagnostic workflows.