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[Thromboembolic diseases in children]
1Barneklinikken, Rikshospitalet, Oslo.
Insights
Pediatric thromboembolic disease is rising, with treatment often extrapolated from adults. This review outlines current concepts and provides guidelines for antithrombotic therapy in children, advocating for broader screening and adult treatment principles.
Area of Science:
- Pediatric Hematology
- Vascular Medicine
- Critical Care Medicine
Context:
- Increasing incidence of pediatric thromboembolic diseases.
- Limited evidence-based guidelines for pediatric treatment.
- Reliance on adult medicine extrapolations for clinical recommendations.
Purpose:
- To present current concepts of pediatric thromboembolic diseases.
- To outline characteristic features and differences from adult disease.
- To provide guidelines for antithrombotic treatment in children.
Summary:
- Reviews literature on pediatric thromboembolic diseases, highlighting unique features.
- Discusses differences in presentation and management compared to adults.
- Offers evidence-based guidelines for antithrombotic therapy and thrombophilia screening.
Impact:
- Informs clinical practice for pediatric thromboembolic disease management.
- Promotes application of modern treatment principles in pediatric care.
- Encourages wider screening for thrombophilic disorders in children.
Abstract:
The incidence of thromboembolic diseases in children is increasing, probably as a consequence of medical progress and modern intensive care. Due to lack of scientific evidence, clinical recommendations for treatment of children are mainly based on opinions and extrapolations from adult medicine. This article presents current concepts of thromboembolic diseases in children, based on a review of the literature. Characteristic features are presented and differences between the disease in adults and children are outlined. Guidelines for antithrombotic treatment are provided. We suggest that screening for thrombophilic disorders should be performed on wide indications, and that modern principles of treatment in adult medicine should also be applied for children with thromboembolic diseases.