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Cysteine chloromethyl and diazomethyl ketone derivatives with potent anti-leukemic activity
D A Perrey1, R K Narla, F M Uckun
1Parker Hughes Cancer Center, Parker Hughes Institute, St. Paul, MN 55113, USA.
Bioorganic & Medicinal Chemistry Letters
|March 31, 2000
Abstract:
A series of cysteine diazomethyl- and chloromethyl ketone derivatives has been synthesized and evaluated against human B-lineage (Nalm-6) and T-lineage (Molt-3) acute lymphoblastic leukemia cell lines. The chloromethyl ketone compounds showed potent cytotoxicity against these cell lines, with IC50 values in the low micromolar range. The best compounds were N-acetyl-S-dodecyl-Cys chloromethyl ketone (IC50 = 2.0 microM against Nalm-6, 2.3 microM against Molt-3) and N-acetyl-S-trans,trans-farnesyl-Cys chloromethyl ketone (IC50 = 3.0 microM against Nalm-6 and 1.4 microM against Molt-3).