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Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand
P A Coates1, P Grundt, E S Robinson
1School of Chemistry, University of Bristol, UK.
Bioorganic & Medicinal Chemistry Letters
|March 31, 2000
Abstract:
An irreversible ligand (7) has been prepared based on the selective I2 ligand 2-BFI. Compound 7 displayed high affinity and selectivity for I2-sites and has been shown to irreversibly bind to these sites in rat brain. Compound 7 should, therefore, prove an invaluable tool for the further elucidation of I2-site function.