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Endomorphin-1, an endogenous mu-opioid receptor-selective agonist, stimulates oxygen consumption in mice
1Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Abstract:
This study was undertaken to investigate the effect of endogenous mu-receptor-selective peptide endomorphin 1, administered intracerebroventricularly, on oxygen consumption in mice. The intracerebroventricular injection of endomorphin 1 (3-30 nmol) significantly increased oxygen consumption in unrestrained mice. The effect of endomorphin 1 (30 nmol) was significantly antagonized by the simultaneous intraperitoneal administration of naloxone (100 nmol). These results suggest that endomorphin 1 stimulates oxygen consumption, and that the mu-opioid receptor influences energy balance in mice.
Insights
Endomorphin 1, a peptide acting on mu-opioid receptors, increases oxygen consumption in mice. This effect is blocked by naloxone, indicating the mu-opioid receptor
Area of Science:
- Neuroscience
- Endocrinology
- Metabolism
Background:
- Endogenous peptides play crucial roles in regulating physiological processes.
- The mu-opioid receptor is involved in various central nervous system functions.
- Energy balance is a complex process influenced by hormonal and neural signals.
Purpose of the Study:
- To investigate the impact of endomorphin 1 on oxygen consumption in mice.
- To determine the role of the mu-opioid receptor in mediating these effects.
Main Methods:
- Intracerebroventricular administration of endomorphin 1 in varying doses (3-30 nmol).
- Measurement of oxygen consumption in unrestrained mice.
- Administration of naloxone (a mu-opioid receptor antagonist) to assess receptor involvement.
Main Results:
- Intracerebroventricular injection of endomorphin 1 significantly elevated oxygen consumption.
- The observed increase in oxygen consumption was dose-dependent.
- Co-administration of naloxone antagonized the effect of endomorphin 1 on oxygen consumption.
Conclusions:
- Endomorphin 1 stimulates oxygen consumption in mice.
- The mu-opioid receptor is implicated in the regulation of energy balance.
- These findings highlight a potential role for endogenous opioids in metabolic control.