Related Experiment Videos
Synthesis of antioxidative and anti-inflammatory drugs glucoconjugates
R K Uhrig1, M A Picard, K Beyreuther
1Zentrum für Molekularbiologie Heidelberg (ZMBH), Germany. r.uhrig@dkfz-heidelberg.de
Carbohydrate Research
|March 31, 2000
Abstract:
Glucoconjugates of (+/-)-ibuprofen, (+/-)-alpha-tocopherol (vitamin E), gentisic acid, gallic acid, 2,6-bis(tert-butyl)-4-thiophenol, and N-acetyl-L-cysteine were prepared with the objective of increasing the bioavailability of such antioxidant and anti-inflammatory drugs. The O-glucosides were synthesized using benzylated alpha-D-glucopyranosyl trichloracetimidate as glycosyl donor. For the synthesis of the S-glucosides, the glycosyl donor 1,2,3,4,6-penta-O-acetyl-beta-D-glucopyranose provided higher yields than the corresponding O-acetylated imidate.