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Related Experiment Videos

Inhaled corticosteroids in childhood asthma: growing concerns.

K B Witzmann1, R J Fink

  • 1Department of Allergy, Immunology, and Pulmonary Medicine, Children's National Medical Center, George Washington University, Washington, DC 20010, USA. Kwitzman@cnmc.org

Drugs
|March 31, 2000
PubMed
Summary

Inhaled corticosteroids (ICS) may impact growth velocity in children with asthma. New FDA labeling highlights this risk, alongside other safety and compliance concerns for pediatric asthma management.

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Area of Science:

  • Pediatric Pulmonology
  • Pharmacovigilance
  • Asthma Management

Background:

  • Inhaled corticosteroids (ICS) are a cornerstone therapy for childhood asthma.
  • Emerging evidence suggests a potential link between ICS use and reduced growth velocity in children.
  • Regulatory bodies like the FDA are reviewing these findings.

Purpose of the Study:

  • To review the established benefits of ICS in pediatric asthma.
  • To examine the association between ICS and potential growth suppression.
  • To discuss updated FDA class labeling and other ICS-related concerns in children.

Main Methods:

  • Literature review of studies on ICS and pediatric growth.
  • Analysis of recent FDA meeting data and labeling changes.

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  • Discussion of adverse effects, usability, and adherence issues.

    • Main Results:

    • ICS are effective for asthma control in children.
    • A potential, though often modest, effect on growth velocity exists with ICS use.
    • New FDA labeling advises caution regarding growth effects.

    Conclusions:

    • The benefits of ICS for asthma control in children generally outweigh potential growth effects.
    • Close monitoring of growth and adherence is recommended.
    • Addressing parental concerns and improving inhaler technique are crucial for effective ICS therapy.