Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anxiety disorders in major depression.

M Fava1, M A Rankin, E C Wright

  • 1Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA.

Comprehensive Psychiatry
|March 31, 2000
PubMed
Summary

Over half of major depression patients have comorbid anxiety disorders, impacting onset and course. Different anxiety disorders show varied temporal relationships with major depressive disorder (MDD).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment effects on residual cognitive symptoms among partially or fully remitted patients with major depressive disorder: A randomized, double-blinded, exploratory study with vortioxetine.

Journal of affective disorders·2019
Same author

Corrigendum to "Activation of kappa opioid receptors in the dorsal raphe have sex dependent effects on social behavior in California mice" [Behav. Brain Res. 351 (2018) 83-92].

Behavioural brain research·2018
Same author

Face and predictive validity of the ClockΔ19 mouse as an animal model for bipolar disorder: a systematic review.

Molecular psychiatry·2017
Same author

Corrigendum to "Randomized, proof-of-concept trial of low dose naltrexone for patients with breakthrough symptoms of major depressive disorder on antidepressants" [J. Affect. Disord. 208 (2017, Jan. 15) 6-14, doi: 10.1016/j.jad.2016.08.029, Epub 2016 Oct. 1].

Journal of affective disorders·2017
Same author

Increased illness burden in women with comorbid bipolar and premenstrual dysphoric disorder: data from 1 099 women from STEP-BD study.

Acta psychiatrica Scandinavica·2017
Same author

Physical Exercise for Treatment of Mood Disorders: A Critical Review.

Current behavioral neuroscience reports·2017

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Mental Health Research

Background:

  • Comorbidity of anxiety disorders with major depressive disorder (MDD) is common.
  • Understanding the prevalence and clinical impact of these comorbidities is crucial for effective treatment.
  • Distinguishing between anxiety secondary to depression and true comorbid anxiety disorders is clinically significant.

Purpose of the Study:

  • To determine the prevalence of anxiety disorder comorbidity in adult outpatients with major depression.
  • To investigate the clinical impact and temporal relationships of various anxiety disorders with MDD.
  • To differentiate between anxiety symptoms secondary to depression and comorbid anxiety disorders.

Main Methods:

  • Cross-sectional study of 255 adult outpatients diagnosed with major depression.

Related Experiment Videos

  • Assessment of comorbid anxiety disorders including social phobia, simple phobia, panic disorder, generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), and agoraphobia.
  • Analysis of the temporal relationship between the onset of anxiety disorders and major depressive disorder.

    • Main Results:

    • 50.6% of patients with major depression had at least one comorbid anxiety disorder.
    • Social phobia and generalized anxiety disorder (GAD) often preceded MDD, while panic disorder and agoraphobia frequently emerged later.
    • Patients with comorbid anxiety disorders tended to be younger during their index episode and have an earlier onset of MDD compared to those with MDD alone.

    Conclusions:

    • Anxiety disorder comorbidity is highly prevalent in major depression.
    • Different anxiety disorders have distinct temporal relationships with the onset and course of major depressive disorder.
    • The findings support the distinction between secondary anxiety symptoms and comorbid anxiety disorders in MDD.