[The study of chronobiology of CT features of liver cancer]

To explore the biological cycle of malignant biological behavior of liver cancer, and to provide a research basis for the excepically specific phase of drugs for clinical treatment of liver cancer.

24 kinds of CT features reflected varying degree of malignant biological behavior. There were 360 cases altogether from randam sampling 30 cases each month. The analytic method is each CT feature fitting a group data of yearly cycle using cosine curve made the analysis of the cyclic sequence character of each CT feature (cosinor).

With 95% confidence, there were 10 CT features which showed biologic rhythm (P < 0.05). The acrophase of CT features for invasive growth concentrated between -60 degrees and -120 degrees (March and April). But for non-invasive growth, the CT features were relatively low and concentrated between -180 degrees and -270 degrees (July and September). No acrophase was shown in between -120 degrees and -180 degrees (May and June) and between -270 degrees and -330 degrees (October and November).

Between CT features of the invasive and non-invasive growths of liver cancer, a sequential difference in biologic cycles can be observed.