[Histological study of experimental reconstructive materials for lateral skull base and dural defect in dogs]

In order to observe the reconstructive effects of fascia lata, superficial fascia and bone morphogenic protein (BMP) in skull base surgery, a lateral skull base bone and dural defect model in dogs was established. Fascia was selected alone or combined with BMP as repairing materials and BMP was evaluated in reconstructing large cranial defect model. Forty dogs underwent a 3.0 x 4.0 cm full-thickness excision of the parietal bone were divided into different groups of five dogs each, and were reconstructed by 1. fascia lata; 2. fascia lata plus BMP; 3. nonreconstructed controls; 4. fascia lata plus BMP and exposed. The implants were harvested at 2-15 weeks and examined histologically. The new bone was found in the BMP. Implants treated and untreated were quite different. The unreconstructed controls demonstrated only a bridge of fibrovascular connective tissue. BMP are defined as osteoinductive by their ability to produce bone formation by stimulating mesenchymal cells to transform into bone-producing osteo-blasts. The results suggested the combination of BMP and reconstructive material in the treatment of bone defects.