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Clinical safety issues of measles, mumps and rubella vaccines

M A Afzal1, P D Minor, G C Schild

  • 1Division of Virology, National Institute for Biological Standards and Control, Hertfordshire, England. mafzal@nibsc.ac.uk

Bulletin of the World Health Organization
|April 1, 2000
PubMed

Insights

This review found no evidence linking measles virus or measles vaccines to juvenile Crohn disease. Independent laboratory investigations confirmed no association, supporting epidemiological findings.

Area of Science:

  • Immunology
  • Gastroenterology
  • Virology

Background:

  • Recent reports suggest a potential link between measles virus/vaccines and juvenile Crohn disease or autism.
  • The clinical safety of measles and measles-mumps-rubella (MMR) vaccines has been questioned.

Purpose of the Study:

  • To review laboratory investigations assessing the presence of measles virus in inflammatory bowel disease tissues.
  • To evaluate the association between measles virus/vaccines and Crohn disease development.

Main Methods:

  • Review of independent laboratory investigations.
  • Analysis of techniques used for measles virus detection in intestinal tissues.
  • Consideration of epidemiological findings.

Main Results:

  • One study reported measles virus presence in inflammatory bowel disease tissues, but this was not reproducible by other independent groups.
  • Highly specific and sensitive molecular techniques failed to confirm measles virus in clinical specimens.
  • Most epidemiological studies do not support a link.

Conclusions:

  • There is no direct association between measles virus or measles vaccines and the development of Crohn disease.
  • The findings do not support a causal link between measles virus and inflammatory bowel disease.

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