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Related Experiment Videos

Functional, histological, and inflammatory changes in chronically rejecting small bowel transplants.

R W de Bruin1, A N Stein-Oakley, E A Kouwenhoven

  • 1Erasmus University, Laboratory for Experimental Surgery, Rotterdam, The Netherlands.

Transplant International : Official Journal of the European Society for Organ Transplantation
|April 1, 2000
PubMed
Summary

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Researchers developed rat models for chronic rejection (CR) in small bowel allografts. Cyclosporin treatment delayed CR, with short-term treatment leading to functional abnormalities and histological changes by 50-100 days post-transplant.

Area of Science:

  • Transplantation immunology
  • Gastroenterology
  • Surgical pathology

Background:

  • Chronic rejection (CR) remains a significant challenge in small bowel transplantation.
  • Understanding the pathological changes in CR is crucial for improving graft survival.
  • Developing reliable animal models is essential for studying CR mechanisms.

Purpose of the Study:

  • To establish and characterize rat models of chronic rejection in small bowel allografts.
  • To investigate the histological and functional changes associated with CR.
  • To evaluate the impact of cyclosporin treatment duration on CR development.

Main Methods:

  • Small bowel transplantation was performed in a DA to AS rat strain combination.
  • Animals received short-term or long-term cyclosporin treatment to prevent acute rejection.

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  • Histological examination and functional assessments (lactulose-mannitol test, serum albumin) were conducted at 50 and 100 days post-transplant.

    • Main Results:

    • Histological signs of CR, including serositis and mesenteric vascular changes, were observed in allografts by 50 and 100 days.
    • Functional abnormalities, evidenced by increased lactulose-mannitol ratio and decreased albumin, were noted in short-term cyclosporin treated groups.
    • Long-term cyclosporin treatment delayed the onset of CR and associated functional deficits.

    Conclusions:

    • Two rat models of chronic rejection in small bowel allografts were successfully developed.
    • Cyclosporin treatment duration influences the development and manifestation of CR.
    • These models provide valuable tools for further research into CR pathogenesis and therapeutic strategies.