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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Influenza pneumonia in a paediatric lung transplant recipient

J L Faul1, O A Akindipe, G J Berry

  • 1Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, CA 94305-5407, USA.

Transplant International : Official Journal of the European Society for Organ Transplantation
|April 1, 2000
PubMed

Insights

Influenza infections are usually mild in lung transplant recipients. However, this case shows severe influenza pneumonia in a pediatric patient, leading to respiratory failure and future complications.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Transplant Surgery

Background:

  • Influenza is a common respiratory illness but typically mild in lung transplant recipients.
  • Previous cases reported transient pulmonary function declines and benign clinical courses.

Observation:

  • A 13-year-old pediatric patient experienced severe influenza pneumonia 5 months post-double lung transplantation.
  • Diagnosis confirmed via direct fluorescent antibody testing and viral culture of bronchoalveolar lavage fluid.

Findings:

  • The patient required mechanical ventilation for 2 days due to respiratory failure.
  • Following recovery, the patient developed obliterative bronchiolitis and is awaiting re-transplantation.

Implications:

  • Severe influenza pneumonia can occur in pediatric lung transplant recipients.
  • This case highlights potential long-term complications, including obliterative bronchiolitis, after influenza infection in this vulnerable population.

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