Jove
Visualize
Contact Us

Related Experiment Videos

Single photon bone densitometry in multiple myeloma.

J Bacovský1, V Scudla, Z Pospísil

  • 1III. Department of Medicine, Medical Faculty of Palacky University, Olomouc, Czech Republic.

Acta Universitatis Palackianae Olomucensis Facultatis Medicae
|April 1, 2000
PubMed
Summary

In multiple myeloma patients, longer disease duration correlated with lower forearm bone mineral density. However, bone density did not link to common osteolysis markers or cytokine levels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Assessment of Heavy/ Light Chain Pairs of Immunoglobulin (Hevylite assay) -  Benefit for Stratification of Multiple Myeloma?].

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2015
Same author

Immunoparesis in MGUS - Relationship of uninvolved immunoglobulin pair suppression and polyclonal immunoglobuline levels to MGUS risk categories.

Neoplasma·2015
Same author

Histomorphometric diagnostics of renal osteopathy in chronic dialysis patients at high risk of cardiovascular disease.

International urology and nephrology·2015
Same author

[Attainment of complete hematological remission is crucial for extended survival of AL amyloidosis patients with cardiac involvement].

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2013
Same author

[The importance of cardiac bio-marker assay for the stratification and monitoring of AL amyloidosis patients -  single center experience].

Vnitrni lekarstvi·2013
Same author

[Treatment of AL amyloidosis in 2012; the benefit of new drugs (bortezomib, thalidomide, and lenalidomide). Summary of published clinical trials].

Vnitrni lekarstvi·2013
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Oncology
  • Bone Metabolism
  • Hematology

Background:

  • Multiple myeloma frequently causes bone disease, impacting patient quality of life.
  • Understanding the relationship between disease progression and bone mineral density is crucial for managing complications.

Purpose of the Study:

  • To investigate the correlation between the duration of multiple myeloma and bone mineral density.
  • To explore the association between bone mineral density and biochemical markers of osteolysis and serum cytokine levels.

Main Methods:

  • The study included 45 patients diagnosed with multiple myeloma.
  • Bone mineral density of the forearm was measured.
  • Urinary pyridinoline and deoxypyridinoline levels, along with serum cytokine concentrations, were assessed.

Main Results:

  • A significant negative correlation was observed between the duration of multiple myeloma and forearm bone mineral density.
  • No significant correlation was found between bone mineral density and urinary pyridinoline or deoxypyridinoline levels.
  • Serum cytokine levels did not show a correlation with bone mineral density in these patients.

Conclusions:

  • Disease duration is a significant factor associated with reduced bone mineral density in multiple myeloma.
  • Standard biochemical markers of osteolysis and serum cytokines may not be reliable indicators of bone density changes in this patient group.

Related Experiment Videos