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Neonatal lupus erythematosus in triplets
Y Yazici1, K Onel, L Sammaritano
1Division of Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA. yaziciy@hss.edu
The Journal of Rheumatology
|April 1, 2000
Summary
Neonatal lupus erythematosus (NLE), an inflammatory condition in newborns, can affect multiple organs. This report details a rare case of NLE occurring in triplets, highlighting its potential occurrence in multiple siblings.
Area of Science:
- Immunology
- Neonatology
- Dermatology
Background:
- Neonatal lupus erythematosus (NLE) is a condition affecting fetuses and newborns.
- It is caused by maternal autoantibodies, specifically anti-Ro(SSA) and anti-La(SSB) antibodies.
- NLE presents with various manifestations including skin, blood, liver, and heart issues.
Purpose of the Study:
- To report a rare instance of neonatal lupus erythematosus (NLE) in triplets.
- To contribute to the understanding of NLE's occurrence in multiple births.
Main Methods:
- Case report description.
- Review of clinical and serological findings in affected neonates.
Main Results:
- Description of NLE presentation in three siblings from a single pregnancy.
- Confirmation of maternal anti-Ro(SSA) and anti-La(SSB) antibodies.
Conclusions:
- Neonatal lupus erythematosus can occur concurrently in multiple siblings, such as triplets.
- This case underscores the importance of considering NLE in neonates born to mothers with specific autoantibodies, especially in multiple gestations.