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Alpha-tocopherol derivatives and wound healing in an experimental model of filtering surgery
J M Larrosa1, V Polo, T Ramirez
1Department of Ophthalmology, Miguel Servet Hospital, Zaragoza, Spain. jlarrosa@encomix.es
Objective:
To describe the effect of alpha-tocopherol derivatives (acetate and acid-succinate) on the histopathological characteristics of the surgical fistula in an experimental model of filtering surgery.
Materials And Methods:
Thirty pigmented rabbits were divided into 3 groups. Twenty-four hours before surgery the animals were injected subconjunctivally with 0.5 mL of solution that depended on the group of treatment: Group 1 (n = 10) 0.75% ethanol in balanced salt solution (BSS); Group 2 (n = 10) 100 microg alph-tocopherol-acetate in 0.75% ethanol in BSS; Group 3 (n = 10) 100 microg alpha-tocopheryl-acid-succinate in 0.75% ethanol in BSS. Histological findings were evaluated 30 days after surgery.
Results:
The groups treated with alpha-tocopherol derivatives showed a higher percentage of persistence of the fistula and better intraocular pressure (IOP) control.
Conclusions:
Alpha-tocopherol derivatives showed antiproliferative properties in this experimental model of filtering surgery.