Related Experiment Videos
Synthesis and biological activities of NB-506 analogues modified at the glucose group
M Ohkubo1, T Nishimura, H Kawamoto
1Banyu Tsukuba Research Institute, Ibaraki, Japan.
Bioorganic & Medicinal Chemistry Letters
|April 1, 2000
Abstract:
A new indolocarbazole compound, NB-506 (1), modified at the glucose group yielded a beta-D-glucopyranoside, J-107,088 (2), which showed potent anticancer activity. A beta-D-ribofuranoside, J-109,534 (3), was found to be 6 times more potent than J-107,088 at inhibiting topoisomerase I.