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(1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents
V Cecchetti1, F Schiaffella, O Tabarrini
1Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy. viola@ruflo.chimfarm.unipg.it
Bioorganic & Medicinal Chemistry Letters
|April 1, 2000
Abstract:
A series of compounds having a piperazine moiety variously linked to the benzothiazine nucleus were synthesized and evaluated for their in vitro alpha-adrenoceptor affinity by radioligand receptor binding assays. Some compounds bearing a oxyalkyl-(2-methoxyphenyl)piperazine side chain were good alpha1-adrenoreceptor ligands.