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Published on: November 11, 2016
Selection of a potent inhibitor of trihydroxynaphthalene reductase by sorting disease control data
D I Liao1, G S Basarab, A A Gatenby
1DuPont Central Research and Development, Experimental Station, Wilmington DE, 19880, USA.
Bioorganic & Medicinal Chemistry Letters
|April 1, 2000
Abstract:
Compounds that control rice blast, but not other crop diseases, were selected for testing as inhibitors of trihydroxynaphthalene reductase of the fungal melanin biosynthetic pathway. A potent inhibitor of the enzyme (2) (Ki = 25 nM) was identified. An X-ray structure of the enzyme-NADPH-2 complex was determined at 2.1 A resolution.

