Related Experiment Videos
Cancellous bone as an antibiotic carrier
1Department of Orthopaedic Surgery, University Hospital, Trondheim, Norway. ewitsoe@online.no
Acta Orthopaedica Scandinavica
|April 1, 2000
Summary
Morselized cancellous bone effectively carries antibiotics both in vitro and in vivo. Antibiotic release profiles were similar between laboratory and animal studies, demonstrating its potential as a drug delivery system.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Pharmacology
Background:
- Morselized cancellous bone is a potential carrier for antibiotics.
- Understanding antibiotic release is crucial for bone graft applications.
Purpose of the Study:
- To compare antibiotic release from morselized cancellous bone processed in vitro and in vivo.
- To evaluate the efficacy of antibiotic-loaded bone as a drug delivery system.
Main Methods:
- Bone cylinders impregnated with 7 antibiotics were processed daily in broth (in vitro).
- Cylinders were implanted intramuscularly in rats (in vivo).
- Antibiotic elution was measured at 1, 3, and 7 days.
Main Results:
- Morselized cancellous bone demonstrated antibiotic-carrying capacity in both experimental settings.
- Similar elution profiles were observed for netilmicin, vancomycin, clindamycin, and rifampicin between in vitro and in vivo conditions.
Conclusions:
- Morselized cancellous bone serves as a viable antibiotic carrier.
- In vitro processing accurately predicts in vivo antibiotic release characteristics.