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Updated: Aug 19, 2026

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion
Published on: April 5, 2016
Clinical measurement, statistical analysis, and risk-benefit: controversies from trials of spinal injury
M B Bracken1, E F Aldrich, D L Herr
1Department of Epidemiology, Yale University School of Medicine, New Haven, Connecticut 06520-8034, USA.
Background:
The National Acute Spinal Cord Injury Studies have been a series of trials assessing the role of pharmacologic agents in the prevention of secondary neuronal damage after acute spinal cord injury.
Methods:
The trials were multicenter randomized, controlled studies.
Results:
Two trials have demonstrated the efficacy of high-dose methylprednisolone in improving neurologic and functional recovery and have shown a reassuring safety profile.
Conclusion:
This study responds to a recent commentary on these trials and examines in particular the roles of clinical measurement, statistical analysis, and risk benefit in assembling evidence for or against innovative therapies.
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