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Cell polarity: Nailing Crumbs to the scaffold
1Developmental Genetics Programme, Krebs Institute, University of Sheffield, Sheffield, S10 2TN, UK.
Current Biology : CB
|April 4, 2000
Abstract:
Recent studies suggest that the cytoplasmic tail of the Crumbs protein establishes membrane territories in polarised epithelial cells by stabilising a PDZ-domain protein complex. The isolation of a human Crumbs homologue required for normal vision revives questions about the role of Crumbs in cell-cell interactions.