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Blood coagulation: The outstanding hydrophobic residues
J L Pellequer1, A J Gale, E D Getzoff
1Department of Molecular Biology, Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla 92037, USA.
Current Biology : CB
|April 4, 2000
Abstract:
Newly determined crystal structures suggest that the membrane-binding C2 domains of blood coagulation cofactors Va and VIIIa bind anionic phospholipids through protruding solvent-exposed hydrophobic residues, aided by a crown of positively charged residues and by specific hydrogen-bonding side chains.