Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regulatory circuits in Caulobacter.

M Osterås1, U Jenal

  • 1Division of Molecular Microbiology, Biozentrum, University of Basel, Basel, CH-4056, Switzerland.

Current Opinion in Microbiology
|April 4, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum for Lori et al., "A Single-Domain Response Regulator Functions as an Integrating Hub To Coordinate General Stress Response and Development in Alphaproteobacteria".

mBio·2018
Same author

A Single-Domain Response Regulator Functions as an Integrating Hub To Coordinate General Stress Response and Development in Alphaproteobacteria.

mBio·2018
Same author

Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication.

Nature·2015
Same author

Whole-Genome Shotgun Sequence of Bacillus amyloliquefaciens Strain UASWS BA1, a Bacterium Antagonistic to Plant Pathogenic Fungi.

Genome announcements·2014
Same author

By-passing in vitro screening--next generation sequencing technologies applied to antibody display and in silico candidate selection.

Nucleic acids research·2010
Same author

The structure-function relationship of WspR, a Pseudomonas fluorescens response regulator with a GGDEF output domain.

Microbiology (Reading, England)·2007
Same journal

The role of the antimicrobial peptide nisin as a clean label food preservative.

Current opinion in microbiology·2026
Same journal

From coarse-grained metabolic rules to fine-grained control of microbial communities.

Current opinion in microbiology·2026
Same journal

Progress in engineered bacterial cancer therapies.

Current opinion in microbiology·2026
Same journal

Constraints on adaptive loss-of-function mutations during microbial metabolic interactions.

Current opinion in microbiology·2026
Same journal

Discovery of novel antimicrobials within microbiomes.

Current opinion in microbiology·2026
Same journal

Beyond the protein lattice: bacterial S-layer glycans - from structure to functional frontier.

Current opinion in microbiology·2026
See all related articles

The transcriptional regulator CtrA controls key cell cycle events in Caulobacter. Its levels and activity are precisely managed through feedback transcription, timed protein breakdown, and phosphorylation-dependent localization.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Cell Biology

Background:

  • The Caulobacter cell cycle is orchestrated by the transcriptional regulator CtrA.
  • CtrA governs essential processes including DNA replication, methylation, and cell division.

Purpose of the Study:

  • To elucidate the regulatory mechanisms controlling CtrA levels and activity.
  • To understand how CtrA integrates signals for cell cycle progression.

Main Methods:

  • Analysis of ctrA gene transcription and feedback regulation.
  • Investigation of CtrA protein stability and timed proteolysis.
  • Study of CtrA phosphorylation and its impact on subcellular localization.

Main Results:

Related Experiment Videos

  • Feedback loops in ctrA transcription contribute to precise CtrA level control.
  • Timed proteolysis ensures appropriate CtrA degradation during the cell cycle.
  • Phosphorylation by sensor kinases modulates CtrA activity and localization.

    • Conclusions:

    • CtrA acts as a master regulator, integrating multiple control layers for cell cycle fidelity.
    • Dynamic regulation of CtrA levels and activity is crucial for Caulobacter development.