Related Experiment Video

Updated: Aug 4, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Worse six-month outcome for patients with multiple stents in a single coronary artery

E Gaxiola1, R E Vlietstra, K F Browne

  • 1Watson Clinic LLP, Lakeland, Florida.

The Journal of Invasive Cardiology
|April 4, 2000
PubMed

Insights

Using multiple stents in a single coronary artery significantly increases repeat target lesion revascularization (RTLR) compared to single stent placement. Optimal treatment for diffuse coronary artery disease requires further definition.

Area of Science:

  • Cardiovascular Interventions
  • Interventional Cardiology
  • Coronary Artery Disease Management

Background:

  • Historical restenosis rates for multiple stents in single coronary arteries were as high as 60%.
  • Limited data existed on outcomes before optimal stent deployment techniques.

Purpose of the Study:

  • To compare the 6-month outcomes of patients receiving multiple Palmaz-Schatz stents versus single stents in the same coronary artery.
  • Evaluate the safety and efficacy of multiple stenting strategies.

Main Methods:

  • A comparative study involving 348 patients with multiple stents and 174 patients with single stents.
  • A 6-month follow-up period was utilized to assess clinical outcomes.

Main Results:

  • Multiple stenting (two or more stents) was associated with a significantly higher rate of repeat target lesion revascularization (RTLR) (22.6%-23.1%) compared to single stenting (10.4%) (p=0.001).
  • No significant differences were observed in myocardial infarction or death rates between single and multiple stent groups within 6 months.
  • Multivariate analysis identified multiple stents, diabetes mellitus, and type C lesions as predictors of RTLR.

Conclusions:

  • Placing two or more stents in a single coronary artery leads to a significantly higher incidence of RTLR compared to single stent placement.
  • The optimal strategy for managing diffuse coronary artery disease remains an area for further investigation.
Abstract

More Related Videos

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

Related Concept Videos

Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Angina II: Classification01:27

Angina II: Classification

Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...